Dual Interference of Hygromycin B with Ribosomal Translocation and with Aminoacyl-tRNA Recognition
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چکیده
منابع مشابه
Role of ribosomal protein S12 in discrimination of aminoacyl-tRNA.
Ribosomes of streptomycin-resistant strains (&r-R) translate genetic messages with fewer errors than ribosomes of streptomycin-sensitive (S&S) strains. I have examined whether the increased level of tRNA discrimination by &r-R ribosomes, relative to Str-S ribosomes, occurs in an initial discrimination step before GTP hydrolysis during enzymatic tRNA binding, or in a second discrimination, or pr...
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We have characterized hisS, the gene encoding the histidyl-tRNA synthetase (HisRS) from the tetraodontoid fish Fugu rubripes. The hisS gene is about 3.5 kbp long and contains 13 exons and 12 introns of 172 bp, on average. The Fugu hisS gene encodes a putative protein of 519 amino acids with the three motifs identified as signatures of class 2 aminoacyl-tRNA synthetases. A model for the shifting...
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15 صفحه اولCoevolution of an aminoacyl-tRNA synthetase with its tRNA substrates.
Glutamyl-tRNA synthetases (GluRSs) occur in two types, the discriminating and the nondiscriminating enzymes. They differ in their choice of substrates and use either tRNAGlu or both tRNAGlu and tRNAGln. Although most organisms encode only one GluRS, a number of bacteria encode two different GluRS proteins; yet, the tRNA specificity of these enzymes and the reason for such gene duplications are ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1978
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1978.tb12347.x